HBTU CAS 94790-37-1 Peptide Coupling Reagent Purity >99.0% (HPLC) Factory

HBTU (CAS: 94790-37-1) is a coupling reagent used in peptide synthesis. HBTU has been shown to effectively suppress racemization.
HBTU is a coupling reagent commonly used in solid phase peptide synthesis. HBTU has also been used in standard Fmoc-based solid-phase peptide synthesis (SPPS) protocol.
HBTU, after being introduced in 1978, HBTU agent shows popularity in chemistry and industry use due to its mild activating properties. moreover, it also shows resistance against racemization. low tendency for racemization is a key requirement for peptide synthesis. especially for solid phase peptide synthesis, quantitative yields with short reaction times are crucial in order to make the synthesis of large peptides feasible.
Recent studies show that crystal as well as solution structure of this coupling agent is a guanidinium N-oxide and not an uronium compound; Coupling reagent for peptide synthesis; advantages are: very low racemization, simple reaction conditions, very short reaction time, and high yields.
Peptide synthesis relied mostly on efficient and safe coupling reagents. HBTU was proved to transform carboxylic acids into azides efficiently and practically. the process might be applied to a wide range of carboxylic acids including n-protected amino acids. in addition, HBTU was of great value in one-pot synthesis of dipeptidyl urea esters, ureas, and carbamates from acids. the advantages of HBTU included the following points: 1) non-explosive and therefore more suitable for solution/solid phase peptide synthesis. 2) high solubility and stability in classical solvents. 3) feasible for colorimetric reaction monitoring.