3-Ethynylaniline CAS 54060-30-9 Purity >99.0% (GC) Erlotinib Hydrochloride Intermediate
Leading manufacturer and supplier of Erlotinib Hydrochloride Intermediates
Erlotinib Hydrochloride | CAS 183319-69-9 |
3-Ethynylaniline | CAS 54060-30-9 |
6,7-Bis(2-Methoxyethoxy)-4(3H)-Quinazolinone | CAS 179688-29-0 |
Please contact: alvin@ruifuchem.com
Chemical Name | 3-Ethynylaniline |
Synonyms | m-Ethynylaniline; 3-Aminophenylacetylene; m-Aminophenylacetylene; 3-Ethynylbenzeneamine; 3-Ethynyl-Phenylamine |
CAS Number | 54060-30-9 |
Stock Status | In Stock, Production Capacity 50MT/Month |
Molecular Formula | C8H7N |
Molecular Weight | 117.15 |
Sensitive | Air Sensitive, Light Sensitive |
Boiling Point | 120℃/20 mmHg |
Water Solubility | Insoluble in Water |
Brand | Ruifu Chemical |
Item | Specifications | Results |
Appearance | Light Yellow to Brown Liquid | Complies |
Purity / Analysis Method | >99.0% (GC) | 99.85% (GC) |
Water by Karl Fischer | <0.50% | 0.02% |
Residue on Ignition | <0.20% | 0.01% |
Total Impurities | <1.00% | 0.15% |
Specific Gravity (20/20℃) | 1.041~1.048 | Complies |
Refractive Index n20/D | 1.614~1.6195 | Complies |
Infrared Spectrum | Conforms to Structure | Complies |
Proton NMR Spectrum | Conforms to Structure | Complies |
Test Standard | Enterprise Standard | Complies |
Usage | Pharmaceutical Intermediate; Erlotinib Hydrochloride Intermediate |
Package: Fluorinated Bottle, 25kg/Drum, or according to customer's requirement
Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture
Risk Codes
36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
S37/39 - Wear suitable gloves and eye/face protection
S36/37 - Wear suitable protective clothing and gloves.
UN IDs UN 1993 3/PG 3
WGK Germany 3
TSCA Yes
HS Code 2921499090
Hazard Class 3
Packing Group Ⅲ
3-Ethynylaniline, also known as 3-Aminophenylacetylene (CAS: 54060-30-9) is used as a pharmaceutical intermediate. 3-Ethynylaniline is an intermediate of Erlotinib Hydrochloride (CAS: 183319-69-9). Erlotinib Hydrochloride is a small molecule tyrosine kinase inhibitor which acts reversibly on epidermal growth receptors, a hydrochloride of erlotinib, a molecular-targeted drug. The US Food and Drug Administration (FDA) has approved erlotinib (Tarceva) combined with gemcitabine as a first-line treatment for locally advanced and metastatic pancreatic cancer. It is mainly used as a second- or third-line treatment for locally advanced or metstatic non-small cell lung cancer (NSCLC) and as a treatment for pancreatic cancer. It is used as a tyrosine inhibitor for NSCLC treatment. Erlotinib Hydrochloride, a quinazoline derived small molecule inhibitor of epidermal growth receptor (EDGFR) tyrosine kinase, was approved in November, 2004, for the treatment of advanced or metastatic non-smallcell lung cancer.